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Microbial byproducts, such as butyrate and propionate, strengthen the intestinal barrier, enhance insulin sensitivity, modulate appetite regulation, and decrease systemic inflammation [22,23]

This approach aligns with emerging evidence that obesity is a chronic condition requiring ongoing management, similar to hypertension or diabetes

A recent 2025 study showed that participants who consumed 1 gram of berberine daily for 6 months had no meaningful change in adiposity (AKA the accumulation of body fat) 19